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In a new study published in the journal Stem Cell Reports, researchers reveal how a combination of stem cell transplantation and antidiabetic medication successfully treated mice with type 2 diabetes.
This image shows the transplanted pancreatic beta cells derived from human embryonic stem cells. Jennifer Bruin, University of British Columbia Senior study author Timothy Kieffer, of the University of British Columbia in Canada, and colleagues say the findings could lead the way for the first ever stem cell-based insulin replacement therapy being tested in humans with type 2 diabetes.
It is estimated that more than 29 million people in the US have diabetes. The condition occurs as a result of the body being unable to produce enough of the hormone insulin or use it effectively. This leads to high blood glucose levels.
In order to manage blood glucose levels, patients with type 2 diabetes are often treated with oral medication - such as metformin - insulin injections, or a combination of both.
Kieffer and colleagues note, however, that such treatments can cause gastrointestinal problems, weight gain and low blood glucose levels, and some patients may not even respond to them.
With these factors in mind, the team tested a potential alternative treatment approach for patients with type 2 diabetes.
Improved glucose metabolism, insulin sensitivity with beta cell transplantation The team created a mouse model of type 2 diabetes by inducing some markers of the disease in the animals - obesitylow response to insulin and high blood glucose levels - by feeding them a high-fat diet.
Next, the team transplanted mice with encapsulated pancreatic progenitor cells derived from human embryonic stem cells.
These cells developed into fully-functioning beta cells - a type of cell in the pancreas that produces insulin - causing the mice to experience better glucose metabolism and an improvement in responsiveness to insulin.
What is more, mice that received stem cell transplantation in combination with antidiabetic medication experienced rapid weight loss, and - compared with either treatment alone - saw greater improvements in glucose metabolism.
Kieffer and colleagues now plan to test whether transplanting more mature beta cells into mouse models of type 2 diabetes - rather than pancreatic progenitor cells - could lead to faster alleviation of symptoms at a lower dose. The researchers believe their approach could reach clinical trials in humans, particularly since a similar technique has recently been approved by the US Food and Drug Administration FDA and Health Canada for testing in patients with type 1 diabetes.
Our hope is that a stem cell-based approach to insulin replacement will ultimately improve glucose control in patients with both type 1 and type 2 diabetes, resulting in healthier, longer lives.
Written by Honor Whiteman?Apr 13, · Stem cell therapy is a promising therapeutic modality for advanced diabetes mellitus (DM). This study presents a meta-analysis of relevant clinical trials . Stem Cell Therapy for Diabetes Essay Words | 5 Pages.
Diabetes, or fully named Diabetes Mellitus is when a person has high blood sugar and that is cause by the lack of insulin produced by the pancreas or it is when the cells do not respond to the insulin produced, it is also according to the type of diabetes that the cause may be different .
Essay The Treatment Of Stem Cell Research. Many people all over the United States and the world suffer untreatable, life threatening diseases. If stem cell research is funded these disease would not only be cured but prevented.
This cure could save ’s of millions of Americans lives and could prevent millions of more cases. The Stem Cells Technology In Diabetes Therapy Biology Essay.
Biotechnology Program School of chemestry & molecular biosciencesEmerging Biotechnologies. Stem Cell Therapy for Diabetes It has been suggested that stem cell therapy is the answer to treating many patients greatly improving their quality of life. [tags: Multicellular Organisms, Stem Cell Therapy] In this essay, I will explain embryonic stem cells concept, and importance of utilizing it in medical development.
Moreover, I. Cell replacement therapy is currently the only stem cell treatment of neurodegenerative diseases such as ALS, but researchers are trying to find new ways of treating and possibly curing ALS.